Dr. Mario is a doctor version of Mario, but is somewhat incompetent. He is best friends with Young Link and his stupidity can often blind him in various situations. For some reason, he has a fascination with Satan and is also the star of The Retarded Adventures of Young Link and Dr. Mario.
- Young Link
- Tomo Takino
- Elmo and his chumps
- Nurse Toadstool (wife/girlfriend/assistant)
- Nurse Redheart (love/hate relationship)